E-ISSN 2475-0581
 

Original Article 


Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder

Ozlem Bas Uluyol, Ozge Sahmelikoglu Onur, Ajda Ekinci, Oya Guclu.

Abstract
Objective: There are many studies showing that cognitive impairment persisted during the remission period in bipolar disorder type 1(BPD1). The end-product of purine catabolism, uric acid, is a natural antioxidant. The purinergic system has a role in the regulation of mood, sleep, energy, cognitive function, and behavior. Several studies have indicated that malfunctioning of the purinergic system might have an impact on the pathophysiology of BPD1. We aimed to compare differences in cognitive functions and serum urate levels between patients with BPD1and healthy controls (HC), and to evaluate the relationship between serum uric acid levels and cognitive functions in the patient group.
Methods: This study included 75 euthymic patients with BPD1 and 75 healthy age- and sex-matched individuals. All participants completed a sociodemographic form, the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Montreal Cognitive Assessment Scale (MoCA), and underwent a neuropsychometric battery; blood serum uric acid levels were also measured. Clinical interviews for Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (SCID-I) and Young Mania Rating Scale (YMRS) scores were obtained for the patients; the HC group was investigated using the SCID non-patient version.
Results: All of the neurocognitive domains, patients showed worse performance than healthy controls (p<0.05). Serum uric acid levels were significantly lower in the BPD1 group than in the HC group (p<0.05). The uric acid levels revealed a statistically significant effect for the differentiation of BPD1 from HC in the regression analysis (p<0.05). There was no statistically significant correlation between uric acid levels and the neurocognitive domains of attention, executive functions and visual memory (p>0.05). A statistically significant negative correlation was observed between uric acid levels and the neurocognitive domains of verbal memory (p<0.05)
Conclusion: A relationship was noted between the rise in serum uric acid levels and the impairment in verbal memory functions in patients with BPD1. Our study is the first to report the relationship between serum uric acid levels and all areas of cognitive functions, including executive functions, verbal and visual memory, and attention, as assessed using neurocognitive batteries, in patients with euthymic BPD1. Uric acid may be a target in the treatment of BPD1, especially in the presence of various cognitive dysfunctions.

Key words: bipolar disorder; cognitive function; uric acid level, biomarker


 
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How to Cite this Article
Pubmed Style

Uluyol OB, Onur OS, Ekinci A, Guclu O. Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(2): 165-174. doi:10.5455/PCP.20200321090156


Web Style

Uluyol OB, Onur OS, Ekinci A, Guclu O. Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. http://www.psychiatryandclinicalpsychopharmacology.org/?mno=94064 [Access: October 01, 2020]. doi:10.5455/PCP.20200321090156


AMA (American Medical Association) Style

Uluyol OB, Onur OS, Ekinci A, Guclu O. Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(2): 165-174. doi:10.5455/PCP.20200321090156



Vancouver/ICMJE Style

Uluyol OB, Onur OS, Ekinci A, Guclu O. Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP. (2020), [cited October 01, 2020]; 30(2): 165-174. doi:10.5455/PCP.20200321090156



Harvard Style

Uluyol, O. B., Onur, . O. S., Ekinci, . A. & Guclu, . O. (2020) Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. Psychiatry and Clinical Psychopharmacology - PCP, 30 (2), 165-174. doi:10.5455/PCP.20200321090156



Turabian Style

Uluyol, Ozlem Bas, Ozge Sahmelikoglu Onur, Ajda Ekinci, and Oya Guclu. 2020. Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. Psychiatry and Clinical Psychopharmacology, 30 (2), 165-174. doi:10.5455/PCP.20200321090156



Chicago Style

Uluyol, Ozlem Bas, Ozge Sahmelikoglu Onur, Ajda Ekinci, and Oya Guclu. "Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder." Psychiatry and Clinical Psychopharmacology 30 (2020), 165-174. doi:10.5455/PCP.20200321090156



MLA (The Modern Language Association) Style

Uluyol, Ozlem Bas, Ozge Sahmelikoglu Onur, Ajda Ekinci, and Oya Guclu. "Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder." Psychiatry and Clinical Psychopharmacology 30.2 (2020), 165-174. Print. doi:10.5455/PCP.20200321090156



APA (American Psychological Association) Style

Uluyol, O. B., Onur, . O. S., Ekinci, . A. & Guclu, . O. (2020) Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder. Psychiatry and Clinical Psychopharmacology, 30 (2), 165-174. doi:10.5455/PCP.20200321090156