E-ISSN 2475-0581
 

Original Article 


Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study

Mahmut Cem Tarakcioglu, Yasin Caliskan, Muhammed Tayyib Kadak, Nilufer Okumus Aliyev, Umut Mert Aksoy, Ali Evren Tufan, Ozlem Yildiz Gundogdu, Nursu Cakin Memik, Margaret D Weiss.

Abstract
OBJECTIVE: To investigate the relationship between symptomatic improvement and functional improvement in children with attention deficit hyperactivity disorder (ADHD) who were being treated with OROS methylphenidate.
METHODS: Parents evaluated the severity of ADHD symptoms on the Turgay-DSM-IV ADHD/Disruptive Behavior Disorders Scale (T-DSM-IV). They assessed functioning on the Weiss Functional Impairment Rating Scale- Parent Form (WFIRS-P), and the Pediatric Quality of Life Inventory (PedsQL) was used to assess quality of life. Clinicians rated global outcome on the Clinical Global Impressions Scale (CGI). Response was measured in terms of the following criteria: a 20% change in symptoms, a CGI-I score that was much improved (2) or very much improved (1), or an improvement of 0.25 (the minimally important difference) on the WFIRS. Improvement in quality of life was defined as ≥ 20% change in PedsQL score.
RESULTS: Sixty-three children completed the study. After 12 weeks, 77.7% of patients met the a priori criteria for treatment response rate. Among patients who exhibited improvement in symptoms, 42.9% also showed improved functioning. Among those who showed improved functioning, 95.5% showed improvement in symptoms. Of patients who showed improvement in symptoms, 34.6% percent also showed improvement in quality of life. Of those who showed improvement in quality of life, 94.4% also showed improvement in symptoms.
CONCLUSIONS: Evaluation of changes in functional improvement, quality of life improvement, and symptom improvement during ADHD treatment enables clinicians to identify individuals whose functional impairment/quality of life persists despite symptom improvement. On that basis, additional treatment interventions can be organized for those individuals.

Key words: attention deficit disorder with hyperactivity, children, quality of life, functional impairment, treatment


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mahmut Cem Tarakcioglu
Articles by Yasin Caliskan
Articles by Muhammed Tayyib Kadak
Articles by Nilufer Okumus Aliyev
Articles by Umut Mert Aksoy
Articles by Ali Evren Tufan
Articles by Ozlem Yildiz Gundogdu
Articles by Nursu Cakin Memik
Articles by Margaret D Weiss
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Tarakcioglu MC, Caliskan Y, Kadak MT, Aliyev NO, Aksoy UM, Tufan AE, Gundogdu OY, Memik NC, Weiss MD. Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(2): 128-135. doi:10.5455/PCP.20200526011248


Web Style

Tarakcioglu MC, Caliskan Y, Kadak MT, Aliyev NO, Aksoy UM, Tufan AE, Gundogdu OY, Memik NC, Weiss MD. Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. http://www.psychiatryandclinicalpsychopharmacology.org/?mno=93695 [Access: September 30, 2020]. doi:10.5455/PCP.20200526011248


AMA (American Medical Association) Style

Tarakcioglu MC, Caliskan Y, Kadak MT, Aliyev NO, Aksoy UM, Tufan AE, Gundogdu OY, Memik NC, Weiss MD. Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. Psychiatry and Clinical Psychopharmacology - PCP. 2020; 30(2): 128-135. doi:10.5455/PCP.20200526011248



Vancouver/ICMJE Style

Tarakcioglu MC, Caliskan Y, Kadak MT, Aliyev NO, Aksoy UM, Tufan AE, Gundogdu OY, Memik NC, Weiss MD. Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. Psychiatry and Clinical Psychopharmacology - PCP. (2020), [cited September 30, 2020]; 30(2): 128-135. doi:10.5455/PCP.20200526011248



Harvard Style

Tarakcioglu, M. C., Caliskan, . Y., Kadak, . M. T., Aliyev, . N. O., Aksoy, . U. M., Tufan, . A. E., Gundogdu, . O. Y., Memik, . N. C. & Weiss, . M. D. (2020) Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. Psychiatry and Clinical Psychopharmacology - PCP, 30 (2), 128-135. doi:10.5455/PCP.20200526011248



Turabian Style

Tarakcioglu, Mahmut Cem, Yasin Caliskan, Muhammed Tayyib Kadak, Nilufer Okumus Aliyev, Umut Mert Aksoy, Ali Evren Tufan, Ozlem Yildiz Gundogdu, Nursu Cakin Memik, and Margaret D Weiss. 2020. Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. Psychiatry and Clinical Psychopharmacology, 30 (2), 128-135. doi:10.5455/PCP.20200526011248



Chicago Style

Tarakcioglu, Mahmut Cem, Yasin Caliskan, Muhammed Tayyib Kadak, Nilufer Okumus Aliyev, Umut Mert Aksoy, Ali Evren Tufan, Ozlem Yildiz Gundogdu, Nursu Cakin Memik, and Margaret D Weiss. "Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study." Psychiatry and Clinical Psychopharmacology 30 (2020), 128-135. doi:10.5455/PCP.20200526011248



MLA (The Modern Language Association) Style

Tarakcioglu, Mahmut Cem, Yasin Caliskan, Muhammed Tayyib Kadak, Nilufer Okumus Aliyev, Umut Mert Aksoy, Ali Evren Tufan, Ozlem Yildiz Gundogdu, Nursu Cakin Memik, and Margaret D Weiss. "Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study." Psychiatry and Clinical Psychopharmacology 30.2 (2020), 128-135. Print. doi:10.5455/PCP.20200526011248



APA (American Psychological Association) Style

Tarakcioglu, M. C., Caliskan, . Y., Kadak, . M. T., Aliyev, . N. O., Aksoy, . U. M., Tufan, . A. E., Gundogdu, . O. Y., Memik, . N. C. & Weiss, . M. D. (2020) Is Functional Improvement Always Correlated with Symptomatic Improvement in Children With Attention-Deficit/Hyperactivity Disorder Managed with Oros Methylphenidate? A Prospective Open-Label Naturalistic Follow-Up Study. Psychiatry and Clinical Psychopharmacology, 30 (2), 128-135. doi:10.5455/PCP.20200526011248